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A single mutation G454A in the P450 CYP9K1 drives pyrethroid resistance in the major malaria vector Anopheles funestus reducing bed net efficacy.

Genetics - 8 Jan 2025

Djoko Tagne Carlos S, Kouamo Mersimine F M, Tchouakui Magellan, Muhammad Abdullahi, Mugenzi Leon J L, Tatchou-Nebangwa Nelly M T, Thiomela Riccado F, Gadji Mahamat, Wondji Murielle J, Hearn Jack, Desire Mbouobda H, Ibrahim Sulaiman S, Wondji Charles S

Abstract excerpt

Metabolic mechanisms conferring pyrethroid resistance in malaria vectors are jeopardizing the effectiveness of insecticide-based interventions, and identification of their markers is a key requirement for robust resistance management. Here, using a field-lab-field approach, we demonstrated that a single mutation G454A in the P450 CYP9K1 is driving pyrethroid resistance in the major malaria vector Anopheles...

Topics

Animals
Anopheles
Pyrethrins
Insecticide Resistance
Mosquito Vectors
Cytochrome P-450 Enzyme System
Malaria
Insecticides
Insecticide-Treated Bednets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insect Proteins

Drosophila melanogaster

Mutation

Mosquito Control

Haplotypes

Source

Open in PubMed Open full text

Identifiers

PMID: 39509710
DOI: 10.1093/genetics/iyae181
PMCID: PMC11708915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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