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Multi‐omics analysis identifies a CYP9K1 haplotype conferring pyrethroid resistance in the malaria vector Anopheles funestus in East Africa

12 May 2022

Abstract excerpt

Metabolic resistance to pyrethroids is a menace to the continued effectiveness of malaria vector controls. Its molecular basis is complex and varies geographically across Africa. Here, we used a multi-omics approach, followed-up with functional validation to show that a directionally selected haplotype of a cytochrome P450, CYP9K1 is a major driver of resistance in Anopheles funestus. A PoolSeq GWAS using...

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Insect Resistance and Genetics
Malaria Research and Control
Mosquito-borne diseases and control

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35546741
DOI: 10.1111/mec.16497

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Multi‐omics analysis identifies a CYP9K1 haplotype conferring pyrethroid resistance in the malaria vector Anopheles funestus in East AfricaPMID 35546741Read ↗

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