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Article

The relationship between tissue inhibitor of metalloproteinases-1 and KCNJ5 mutation in aldosterone-producing adenoma patients.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Feb 2025

Lin No-Ting, Chen Tsung-Yan, Wu Xue-Ming, Chang Yi-Yao, Tsai Cheng-Hsuan, Liao Che-Wei, Lai Tai-Shuan, Chang Chin-Chen, Lee Bo-Ching, Lu Ching-Chu, Chueh Jeff Shih-Chieh, Wu Vin-Cent, Hung Chi-Sheng, Chen Zheng-Wei, Lin Yen-Hung

Abstract excerpt

KCNJ5 somatic mutations in aldosterone-producing adenoma (APA) are linked to higher left ventricular mass index (LVMI) and worse diastolic function. We previously identified an association between plasma tissue inhibitor of metalloproteinases-1 (TIMP-1) and an aldosterone-induced increase in LVMI and diastolic dysfunction. This study aimed to investigate the association between the presence of KCNJ5 somatic...

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Share to Adenoma
Share to Adrenal Cortex Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

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Source

Identifiers

PMID: 39690251
DOI: 10.1038/s41440-024-02030-w

Genes

KCNJ5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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The relationship between tissue inhibitor of metalloproteinases-1 and KCNJ5 mutation in aldosterone-producing adenoma patients.PMID 39690251Read ↗

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