Article
Colposcopy referrals and CIN3 detection after triage by host cell DNA methylation and/or HPV genotyping in HPV positive women with low-grade cytology from a population-based Dutch primary HPV screening trial.
International journal of cancer - 1 Mar 2025
Verhoef Lisanne, Bleeker Maaike C G, Polman Nicole, Kroon Kelsi R, Steenbergen Renske D M, Ebisch Renée M F, Melchers Willem J G, Bekkers Ruud L M, Molijn Anco C, van Kemenade Folkert, Meijer Chris J L M, Heideman Daniëlle A M, Berkhof Johannes
Abstract excerpt
High-risk HPV (hrHPV)-based screening has led to many unnecessary colposcopy referrals, mainly because of direct referral after low-grade cytology (ASC-US/LSIL). DNA methylation and genotyping tests on ASC-US/LSIL samples have the potential to significantly improve the efficiency of screening. In this study, 12 triage strategies were constructed from FAM19A4/miR124-2 or ASCL1/LHX8 methylation, HPV16/18 or...
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