Article
Adverse genomic alterations and stemness features are induced by field cancerization in the microenvironment of hepatocellular carcinomas.
Oncotarget - 25 Jul 2017
Castven Darko, Fischer Michael, Becker Diana, Heinrich Stefan, Andersen Jesper B, Strand Dennis, Sprinzl Martin F, Strand Susanne, Czauderna Carolin, Heilmann-Heimbach Stefanie, Roessler Stephanie, Weinmann Arndt, Wörns Marcus A, Thorgeirsson Snorri S, Galle Peter R, Matter Matthias S, Lang Hauke, Marquardt Jens U
Abstract excerpt
Hepatocellular Carcinoma (HCC) commonly develops in chronically damaged liver tissues. The resulting regenerative and inflammatory processes create an adverse milieu that promotes tumor-initiation and progression. A better understanding of the hepatic tumor-microenvironment interaction might infer profound therapeutic implications.Integrative whole genome and transcriptome analyses of different tumor regions, the...
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