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Study on the causality of cathepsin on autoimmune diseases and cancer: evidence from mendelian randomization analysis.

Archives of dermatological research - 14 Dec 2024

Gao Xue, Zhao Xinyu, Yang Shuhan, Liu Jianli, Liu Dan

Abstract excerpt

The genetic causality between cathepsin levels and autoimmune diseases (ADs) bidirectionally was investigated and the associated cancer risk was explored with Mendelian randomization. Mendelian randomization analyses were used to explore causal associations between cathepsin and 14 ADs. The final results came from a meta-analysis of two datasets to get a robust result. Furthermore, the potential carcinogenic...

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Autoimmune Diseases
Breast Neoplasms
Cathepsin L
Cathepsins
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 39673556
DOI: 10.1007/s00403-024-03607-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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