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Pan-cancer analysis of B3GNT5 with potential implications for cancer immunotherapy and cancer stem cell stemness

13 Dec 2024

Abstract excerpt

B3GNT5, a critical member of the β-1,3-N-acetylglucosaminyl transferase gene family involved in lactose and glycosphingolipids biosynthesis, has been documented to promote tumor-infiltrating T-cell responses. Our research utilized the Pan-Cancer dataset from The Cancer Genome Atlas (TCGA) to explore the functional role of B3GNT5. Our study demonstrated that the antibody-driven inhibition of B3GNT5 diminished T...

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PMID: 39671359
DOI: 10.1371/journal.pone.0314609

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