Article
Polygenic risk score for acute rejection based on donor-recipient non-HLA genotype mismatch.
PloS one - 1 Jan 2024
Cao Rui, Schladt David P, Dorr Casey, Matas Arthur J, Oetting William S, Jacobson Pamala A, Israni Ajay, Chen Jinbo, Guan Weihua
Abstract excerpt
BACKGROUND: Acute rejection (AR) after kidney transplantation is an important allograft complication. To reduce the risk of post-transplant AR, determination of kidney transplant donor-recipient mismatching focuses on blood type and human leukocyte antigens (HLA), while it remains unclear whether non-HLA genetic mismatching is related to post-transplant complications. METHODS: We carried out a genome-wide scan...
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