Article
Sustained antiviral insulin signaling during West Nile virus infection results in viral mutations.
Frontiers in cellular and infection microbiology - 1 Jan 2024
Char Aditya B, Trammell Chasity E, Fawcett Stephen, Chauhan Manish, Debebe Yared, Céspedes Nora, Paslay Ryder A, Ahlers Laura R H, Patel Dharmeshkumar, Luckhart Shirley, Goodman Alan G
Abstract excerpt
Arthropod-borne viruses or arboviruses, including West Nile virus (WNV), dengue virus (DENV), and Zika virus (ZIKV) pose significant threats to public health. It is imperative to develop novel methods to control these mosquito-borne viral infections. We previously showed that insulin/insulin-like growth factor-1 signaling (IIS)-dependent activation of ERK and JAK-STAT signaling has significant antiviral activity...
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