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Article

A conserved role for AKT in the replication of emerging flaviviruses in vertebrates and vectors

9 Aug 2024

Abstract excerpt

One third of all emerging infectious diseases are vector-borne, with no licensed antiviral therapies available against any vector-borne viruses. Zika virus and Usutu virus are two emerging flaviviruses transmitted primarily by mosquitoes. These viruses modulate different host pathways, including the PI3K/AKT/mTOR pathway. Here, we report the effect on ZIKV and USUV replication of two AKT inhibitors, Miransertib...

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Identifiers

PMID: 39117146
DOI: 10.1016/j.virusres.2024.199447

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