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Article

Role of 1q21 in Multiple Myeloma: From Pathogenesis to Possible Therapeutic Targets

1 Jun 2021

Abstract excerpt

Multiple myeloma (MM) is characterized by an accumulation of malignant plasma cells (PCs) in the bone marrow (BM). The amplification of 1q21 is one of the most common cytogenetic abnormalities occurring in around 40% of de novo patients and 70% of relapsed/refractory MM. Patients with this unfavorable cytogenetic abnormality are considered to be high risk with a poor response to standard therapies. The gene(s)...

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PMID: 34205916
DOI: 10.3390/cells10061360

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