Article
Mendelian Randomization Study Investigating the Causal Relationship Between Thyroid Dysfunction and Cerebral Infarction.
Brain and behavior - 1 Dec 2024
Li Letai, Leng Jiajie, Xiong Haibing, Deng Zishan, Ye Meng, Wang Haiyan, Guo Xin, Zeng Shi, Xiong Haofeng, Huo Jianhong
Abstract excerpt
BACKGROUND: There is an association between thyroid dysfunction and cerebral infarction (CI), but the causality cannot be determined. A two-sample two-way Mendelian randomization (MR) study was conducted to assess the causal relationship between thyroid function and CI. METHODS: We selected single-nucleotide polymorphisms (SNPs) associated with five phenotypes, including CI from the UK Biobank (n = 361,194),...
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