Genetic predisposition meets cytokine imbalance: the influence of TNF-α (-308) polymorphism and TGF-β levels in pediatric acute lymphoblastic leukemia in Egypt.

doi:10.1186/s12885-024-13224-3

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Genetic predisposition meets cytokine imbalance: the influence of TNF-α (-308) polymorphism and TGF-β levels in pediatric acute lymphoblastic leukemia in Egypt.

BMC cancer - 10 Dec 2024

Radwan Roqaia E, El-Kholy Wafaa M, Elsaed Afaf, Darwish Ahmad

Abstract excerpt

Evading apoptosis fuels the aggressive nature of acute lymphoblastic leukemia (ALL). This study explored the potential roles of TNF-α, a pro-apoptotic cytokine, and TGF-β, a pro-proliferative factor, in the risk of developing ALL in Egyptian children. We investigated the TNF-α rs1800629 polymorphism and serum TGF-β levels in 100 ALL patients and 100 healthy controls. Notably, specific variations in TNF-α (GA, AA...

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PMID: 39658797
DOI: 10.1186/s12885-024-13224-3
PMCID: PMC11629532

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