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MIP4IBD: An Easy and Rapid Genotyping-by-Sequencing Assay for the Inflammatory Bowel Diseases Risk Loci.

Inflammatory bowel diseases - 3 Mar 2025

Verstockt Sare, Hannes Laurens, Jans Deborah Sarah, Deman Stephanie, Souche Erika, van der Werf Ilse, Vandermeulen Liv, Lobaton Triana, Laukens Debby, Verstockt Bram, Van Houdt Jeroen, Hoischen Alexander, Vermeire Séverine, Cleynen Isabelle

Abstract excerpt

BACKGROUND: Inflammatory bowel diseases (IBD) are polygenic, with many genetic variants contributing to disease risk. Knowing the genotype of specific variants or calculating a combined genetic risk score benefits translational and functional research. To address this, we developed MIP4IBD, a flexible and cost-effective genotyping-by-sequencing assay using molecular inversion probes (MIPs). METHODS: The assay...

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Topics

Humans
Inflammatory Bowel Diseases
Genetic Predisposition to Disease
Genotyping Techniques
Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Polymorphism, Single Nucleotide

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Male

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PMID: 39657915
DOI: 10.1093/ibd/izae289

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