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Article

Glutathionylation at Cys-111 induces dissociation of wild type and FALS mutant SOD1 dimers.

Biochemistry - 16 Aug 2011

Redler Rachel L, Wilcox Kyle C, Proctor Elizabeth A, Fee Lanette, Caplow Michael, Dokholyan Nikolay V

Abstract excerpt

Mutation of the ubiquitous cytosolic enzyme Cu/Zn superoxide dismutase (SOD1) is hypothesized to cause familial amyotrophic lateral sclerosis (FALS) through structural destabilization leading to misfolding and aggregation. Considering the late onset of symptoms as well as the phenotypic variability among patients with identical SOD1 mutations, it is clear that nongenetic factor(s) impact ALS etiology and disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21739997
DOI: 10.1021/bi200614y
PMCID: PMC3281512

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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