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A genome-wide association study identifies eight loci associated with intraductal papillary mucinous neoplasm progression toward malignancy.

Cancer - 1 Jan 2025

Gentiluomo Manuel, Corradi Chiara, Apadula Laura, Comandatore Annalisa, Lauri Gaetano, Rossi Gemma, Peduzzi Giulia, Crippa Stefano, Rizzato Cosmeri, Falconi Massimo, Arcidiacono Paolo Giorgio, Morelli Luca, Capurso Gabriele, Campa Daniele

Abstract excerpt

BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are precursors to pancreatic cancer, but not all IPMNs progress to cancer. The objective of this study was to identify the germline genetic variants associated with IPMN clinical progression by conducting the first genome-wide association study (GWAS) and computing a polygenic hazard score (PHS) in 338 patients with IPMN. METHODS: The study population...

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Share to Adenocarcinoma, Mucinous
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Pancreatic Ductal

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 39639588
DOI: 10.1002/cncr.35678
PMCID: PMC11694541

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