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Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression

1 Feb 2025

Abstract excerpt

Chronological age is an imperfect estimate of molecular aging. Epigenetic age, derived from DNA methylation data, provides a more nuanced representation of aging-related biological processes. We examine the bidirectional relationship between epigenetic age and brain health events (stroke, dementia, late-life depression) using data from 4,018 participants. Participants with a prior brain health event are 4%...

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PMID: 39893209
DOI: 10.1038/s41467-024-54721-0

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