Investigating the Mediating Role of Mental Disorders in the Relationship Between Early Sexual Intercourse and Intentional Self-Harm: A Two-Step and Multivariable Mendelian Randomization Study.

Abstract excerpt

BACKGROUND: Epidemiological studies have established an association between early sexual intercourse and intentional self-harm. However, the causal mechanisms, particularly the role of mental health disorders, remain elusive. METHODS: In this Mendelian randomization (MR) study, we leveraged genome-wide association study data from multiple sources. Age at first sexual intercourse (AFSI) statistics were derived...

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