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Article

Studying individual risk factors for self-harm in the UK Biobank: A polygenic scoring and Mendelian randomisation study.

PLoS medicine - 1 Jun 2020

Lim Kai Xiang, Rijsdijk Frühling, Hagenaars Saskia P, Socrates Adam, Choi Shing Wan, Coleman Jonathan R I, Glanville Kylie P, Lewis Cathryn M, Pingault Jean-Baptiste

Abstract excerpt

BACKGROUND: Identifying causal risk factors for self-harm is essential to inform preventive interventions. Epidemiological studies have identified risk factors associated with self-harm, but these associations can be subject to confounding. By implementing genetically informed methods to better account for confounding, this study aimed to better identify plausible causal risk factors for self-harm. METHODS AND...

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Identifiers

PMID: 32479557
DOI: 10.1371/journal.pmed.1003137
PMCID: PMC7263593

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