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Article

Novel candidate plasma proteins for the pathogenesis and treatment of atopic dermatitis revealed by proteome-wide association study.

Scientific reports - 3 Dec 2024

Luo Chen, Zhang YaJing, Feng QiFan, Yao KaiXin, Zheng LeiLei, Yang Ye, Zheng WenXin, Li Feng, Lv YongQiang, Cai Yue

Abstract excerpt

Atopic dermatitis (AD) is an immune-related skin disease with a genetic background. Numerous loci have been identified associated with AD to better comprehend its complicated genetic mechanisms by genome‑wide association studies (GWASs). However, current studies reveal the underlying mechanisms of these loci in the pathogenesis of AD inadequately. Therefore, we integrated the GWAS statistics of AD with plasma...

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Bayes Theorem
Blood Proteins
Dermatitis, Atopic
Genome-Wide Association Study
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Quantitative Trait Loci

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Identifiers

PMID: 39627291
DOI: 10.1038/s41598-024-79906-x
PMCID: PMC11615279

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