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Article

β-asarone relieves Parkinson's disease through reducing intracellular Ca2+ in PINK1 mutant Drosophila melanogaster.

European journal of pharmacology - 15 Jan 2025

Yin Lanxiang, Yuan Xintong, Yu Jiahui, Ren Xuemin, Zhang Hongqin, Ye Yunyan, Wang Zixuan, Chen Xiangtao

Abstract excerpt

β-asarone, an effective volatile oil component of Acorus chinensis, has been found to hold beneficial effects on Parkinson's disease (PD), but its mechanism remains incompletely understood. Drosophila melanogaster with PTEN induced kinase 1 (PINK1) mutations, a prototype PD model, was used in this study. We found that calcium chelation profoundly alleviated a spectrum of PD symptoms. Whereas, calcium...

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PMID: 39622404
DOI: 10.1016/j.ejphar.2024.177155

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