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Restoration of hair follicle inductive properties by depletion of senescent cells

29 Nov 2024

Abstract excerpt

Senescent cells secrete a senescence-associated secretory phenotype (SASP), which can induce senescence in neighboring cells. Human dermal papilla (DP) cells lose their original hair inductive properties when expanded in vitro, and rapidly accumulate senescent cells in culture. Protein and RNA-seq analysis revealed an accumulation of DP-specific SASP factors including IL-6, IL-8, MCP-1, and TIMP-2. We found that...

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PMID: 39614601
DOI: 10.1111/acel.14353

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