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Article

Reduction of senescence-associated secretory phenotype and exosome-shuttled miRNAs by Haritaki fruit extract in senescent dermal fibroblasts.

International journal of cosmetic science - 1 Aug 2023

Bogdanowicz Patrick, Roullet Nicolas, Bensadoun Paul, Bessou-Touya Sandrine, Lemaitre Jean-Marc, Duplan Hélène

Abstract excerpt

OBJECTIVE: Skin ageing is linked to the accumulation of senescent cells and a "senescence-associated secretory phenotype" (SASP). SASP factors include chemokines, cytokines, and small extracellular vesicles (EVs) containing miRNAs. We characterized SASP profile markers in normal human dermal fibroblasts (HDFs) and evaluated the effect of Haritaki fruit extract on these senescence markers. METHODS: Senescence was...

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PMID: 36940283
DOI: 10.1111/ics.12858

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