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From Spheroid to Sprouting: Microenvironmental Modulation Boosts Hair Follicle Organoid Morphogenesis in 3D Culture

4 Jun 2025

Abstract excerpt

Alopecia represents a global therapeutic challenge, with the challenge of achieving de novo folliculogenesis in alopecic regions rather than reactivating telogen-phase hair follicles to enhance hair density. The successful in vitro cultivation of hair follicle organoids (HFOs) and the effective enhancement of HFOs sprouting rates are critical advancements in addressing this problem. While R-spondin1 (RSPO1)...

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PMID: 40464526
DOI: 10.1002/cbin.70045

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