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Biological and genetic characterization of a newly established human primary multidrug-resistant distal cholangiocarcinoma cell line, CBC3T-6.

Scientific reports - 29 Nov 2024

Bai Mingzhen, Wang Ruoshui, Huang Chongfei, Zhong Ruyang, Jiang Ningzu, Fu Wenkang, Mi Ningning, Gao Long, Jin Yuyao, Ma Haidong, Cao Jie, Yu Haiying, Jing Qiang, Zhang Chao, Yue Ping, Zhang Yong, Lin Yanyan, Zhang Hengwei, Meng Wenbo

Abstract excerpt

Distal cholangiocarcinoma is a rare and highly aggressive malignant tumor. The inherent tumor characteristics and growth pattern of cancer cells pose a challenge for diagnosis and treatment. Chemotherapy resistance leads to limited treatment options for patients with advanced cholangiocarcinoma. However, drug resistance studies in cholangiocarcinoma are often limited by the use of preclinical models that do not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39613883
DOI: 10.1038/s41598-024-81392-0
PMCID: PMC11607416

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