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Article

Phenotypic and genomic changes in enteric Klebsiella populations during long-term ICU patient hospitalization: the role of RamR regulation.

mSphere - 19 Dec 2024

Langlois Benedicte, Guerin Francois, Isnard Christophe, Gakuba Clement, Du Cheyron Damien, Giard Jean-Christophe, Brisse Sylvain, Le Hello Simon, Gravey Francois

Abstract excerpt

Acquired antimicrobial resistance and metabolic changes are central for bacterial host adaptation during the long-term hospitalization of patients. We aimed to analyze the genomic and phenotypic evolution of enteric Klebsiella populations in long-term intensive care unit (ICU) patients. Weekly rectal swabs were prospectively collected from all patients admitted to the ICU in a teaching hospital from December 2018...

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Identifiers

PMID: 39611855
DOI: 10.1128/msphere.00704-24
PMCID: PMC11656808

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