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IMP2 drives chemoresistance by repressing cisplatin-induced apoptosis and ferroptosis via activation of IPO4 and SLC7A11 under hypoxia in bladder cancer

22 Nov 2024

Abstract excerpt

BACKGROUND: Cisplatin resistance is the leading cause of mortality in muscle-invasive bladder cancer (MIBC) cases. Previous evidence suggests that abnormal epitranscriptome modifications are associated with reduced chemotherapy responses. However, the exact underlying mechanism remains largely unknown. METHODS: Insulin-like growth factor-2 mRNA-binding protein 2 (IMP2) was identified by clustered regularly...

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PMID: 39578867
DOI: 10.1186/s12935-024-03570-4

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