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Polyploid cancer cells reveal signatures of chemotherapy resistance

22 Nov 2024

Abstract excerpt

Therapeutic resistance in cancer significantly contributes to mortality, with many patients eventually experiencing recurrence after initial treatment responses. Recent studies have identified therapy-resistant large polyploid cancer cells in patient tissues, particularly in late-stage prostate cancer, linking them to advanced disease and relapse. Here, we analyzed bone marrow aspirates from 44 advanced prostate...

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PMID: 39578659
DOI: 10.1038/s41388-024-03212-z

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