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Article

Emergence of carbapenem resistance in persistent Shewanella algae bacteremia: the role of pdsS G547W mutation in adaptive subpopulation dynamics.

Annals of clinical microbiology and antimicrobials - 20 Nov 2024

Huang Yao-Ting, Liu Po-Yu

Abstract excerpt

This study elucidates the in vivo genetic mechanisms contributing to the emerging resistance to carbapenem in Shewanella algae through a lens of adaptive microbial evolution. Leveraging PacBio amplification-free sequencing, we tracked the evolution of β-lactam resistance in clinical isolates from a persistent S. algae bacteremia case amidst antimicrobial therapy. Our investigation spotlighted a recurrent G547W...

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Identifiers

PMID: 39568026
DOI: 10.1186/s12941-024-00759-3
PMCID: PMC11580497

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