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Soluble forms of CD46 are detected in Bos taurus plasma and neutralize BVDV, the bovine pestivirus.

Comparative immunology, microbiology and infectious diseases - 1 Dec 2016

Alzamel Nidal, Bayrou Calixte, Decreux Annabelle, Desmecht Daniel

Abstract excerpt

The pestivirus bovine viral diarrhea virus (BVDV) is known to bind to the CD46 molecule, which subsequently promotes entry of the virus. Mapping of the BVD-virion-binding site has shown that two peptides, 66EQIV69 and 82GQVLAL87, located on antiparallel beta sheets in the most distal complement control protein module (CCP1), provide the attachment platform. In the present study, we reveal new CD46-encoding...

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PMID: 27865262
DOI: 10.1016/j.cimid.2016.09.001

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