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Article

Multilayered Cryogel Enriched with Exosomes Regenerates and Maintains Cartilage Architecture and Phenotype in Goat Osteochondral Injuries.

ACS applied materials & interfaces - 27 Nov 2024

Nikhil Aman, Gugjoo Mudasir Bashir, Das Ankita, Manzoor Tasaduq, Ahmad Syed Mudasir, Ganai Nazir Ahmad, Kumar Ashok

Abstract excerpt

Treatment of critical-size osteochondral (OC) injuries at load-bearing sites has remained a major clinical challenge in orthopedic surgery. This is due to the anisotropic characteristics of OC tissue and the stratified structure of the cartilage. Here, we developed a multilayered OC scaffold by employing cryogelation technology. Gelatin, chitosan, and chondroitin sulfate were utilized for designing three...

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Identifiers

PMID: 39555858
DOI: 10.1021/acsami.4c13808

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