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Article

Somatic co‐alteration signatures are prognostic in high‐grade TP53 ‐mutated myeloid neoplasms

17 Nov 2024

Abstract excerpt

To assess the relevance of co-occurring somatic mutations in TP53-mutated myeloid neoplasms with ≥10% blasts, we pooled 325 individuals from 10 centres. We focused on comparing three published somatic co-alteration signatures comprising (1) nine MDS-related genes ('ICC-MDSR'), (2) ICC-MDSR + additional secondary mutations-related genes ('Tazi signature') and (3) EPI6 (comprising six genes). Outcomes examined were...

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PMID: 39551719
DOI: 10.1111/bjh.19895

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