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Article

Dysregulation of Iron Homeostasis Mediated by FTH Increases Ferroptosis Sensitivity in TP53-Mutant Glioblastoma.

Neuroscience bulletin - 1 Apr 2025

Huan Xuejie, Li Jiangang, Chu Zhaobin, Zhang Hongliang, Cheng Lei, Lun Peng, Du Xixun, Chen Xi, Jiao Qian, Jiang Hong

Abstract excerpt

Iron metabolism is a critical factor in tumorigenesis and development. Although TP53 mutations are prevalent in glioblastoma (GBM), the mechanisms by which TP53 regulates iron metabolism remain elusive. We reveal an imbalance iron homeostasis in GBM via TCGA database analysis. TP53 mutations disrupted iron homeostasis in GBM, characterized by elevated total iron levels and reduced ferritin (FTH). The...

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Identifiers

PMID: 39666195
DOI: 10.1007/s12264-024-01322-y
PMCID: PMC11978602

Genes

TP53
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Dysregulation of Iron Homeostasis Mediated by FTH Increases Ferroptosis Sensitivity in TP53-Mutant Glioblastoma.PMID 39666195Read ↗

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