Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interplay of human ABCC11 transporter gene variants with axillary skin microbiome functional genomics.

Scientific reports - 14 Nov 2024

Stevens Bruce R, Roesch Luiz F W

Abstract excerpt

The human armpit microbiome is metabolically entangled with skin cell physiology. This "meta-organism" symbiotic mutualism results in sweat either with or without odor (osmidrosis), depending on host ABCC11 gene haplotypes. Apocrine metabolism produces odorless S-glutathione conjugate that is transferred by ABCC11 transporters into secretory vesicles, deglutamylated to S-Cys-Gly-3M3SH thiol, and exuded to skin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP-Binding Cassette Transporters
Share to Genomics
Share to Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microbiota

Share to Pedigree

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 39543265
DOI: 10.1038/s41598-024-78711-w
PMCID: PMC11564711

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interplay of human ABCC11 transporter gene variants with axillary skin microbiome functional genomics.PMID 39543265Read ↗

Functional characterisation of a SNP in the ABCC11 allele - effects on axillary skin metabolism, odour generation and associated behaviours.Semantic proximity Read ↗

The specific biochemistry of human axilla odour formation viewed in an evolutionary contextSemantic proximity Read ↗

Association of HLA-DPB1, NLRP10, OVOL1, and ABCC11 with the axillary microbiome in a Japanese population.Semantic proximity Read ↗

Geographic Variation and Host Genetics Shape the Human Skin MicrobiomeSemantic proximity Read ↗

Predictive Metagenomic Profiling, Urine Metabolomics, and Human Marker Gene Expression as an Integrated Approach to Study Alopecia AreataSemantic proximity Read ↗

Skin microbiome composition and function in the development of atopic diseases during infancySemantic proximity Read ↗

Dysbiotic Lesional Microbiome With Filaggrin Missense Variants Associate With Atopic Dermatitis in India.Semantic proximity Read ↗

Cobamide Sharing Is Predicted in the Human Skin MicrobiomeSemantic proximity Read ↗

Stratum corneum lipidomics analysis reveals altered ceramide profile in atopic dermatitis patients across body sites with correlated changes in skin microbiomeSemantic proximity Read ↗

From Allelic Heterogeneity to Biomechanical Phenotypes: A Functional New Genomic Model of ABCC11 Polymorphisms and Their Role in Human Chemical EcologySemantic proximity Read ↗

Characterization of the human skin resistome and identification of two microbiota cutotypesSemantic proximity Read ↗

Influence of FLG loss-of-function mutations in host-microbe interactions during atopic skin inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.