Functional characterisation of a SNP in the ABCC11 allele - effects on axillary skin metabolism, odour generation and associated behaviours.

doi:10.1016/j.jdermsci.2013.08.016

Article

Functional characterisation of a SNP in the ABCC11 allele - effects on axillary skin metabolism, odour generation and associated behaviours.

Journal of dermatological science - 1 Jan 2014

Harker Mark, Carvell Ann-Marie, Marti Vernon P J, Riazanskaia Svetlana, Kelso Hailey, Taylor David, Grimshaw Sally, Arnold David S, Zillmer Ruediger, Shaw Jane, Kirk Jayne M, Alcasid Zee M, Gonzales-Tanon Sheila, Chan Gertrude P, Rosing Egge A E, Smith Adrian M

Abstract excerpt

BACKGROUND: A single nucleotide polymorphism (SNP), 538G→A, leading to a G180R substitution in the ABCC11 gene results in reduced concentrations of apocrine derived axillary odour precursors. OBJECTIVE: Determine the axillary odour levels in the SNP ABCC11 genotype variants and to investigate if other parameters associated with odour production are affected. METHODS: Axillary odour was assessed by subjective...

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Functional characterisation of a SNP in the ABCC11 allele - effects on axillary skin metabolism, odour generation and associated behaviours.

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