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Successful strategies for expression and purification of ABC transporters

12 Nov 2024

Abstract excerpt

ATP-binding cassette (ABC) transporters are proteins responsible for active transport of various compounds, from small ions to macromolecules, across membranes. Proteins from this superfamily also pump drugs out of the cell resulting in multidrug resistance. Based on the cellular functions of ABC-transporters they are commonly associated with diseases like cancer and cystic fibrosis. To understand the molecular...

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PMID: 39537006
DOI: 10.1016/j.bbamem.2024.184401

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