Proteomics Reveals Age as Major Modifier of Inflammatory CSF Signatures in Multiple Sclerosis

Abstract excerpt

BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) can start as relapsing or progressive. While their clinical features and treatment responses are distinct, it has remained uncertain whether their pathomechanisms differ. A notable age-related effect on MS phenotype and response to immunotherapies is well acknowledged, but the underlying pathophysiologic reasons are yet to be fully elucidated. We aimed to...

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