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Article

A novel bioassay for thyroid-blocking immunoglobulins

29 Oct 2024

Abstract excerpt

Background Thyroid-blocking immunoglobulins (TBI) are present in 10%–15% of patients with autoimmune thyroid disease (AITD). TBI affect thyroid function. The analytical performance of a novel TBI bioassay was evaluated. Methods Sera from AITD patients were tested with a cell-based TBI reporter bioassay (Thyretain®) with the expression of a luciferase transgene as readout and a new “Turbo™” TBI bioassay with a...

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PMID: 39534254
DOI: 10.3389/fendo.2024.1463379

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