Article
Phenotypes of interferon-α-induced thyroid dysfunction among patients treated for hepatitis C are associated with pretreatment serum TSH and female sex.
The Journal of clinical endocrinology and metabolism - 1 Sept 2012
Mammen Jennifer S, Ghazarian Sharon R, Pulkstenis Erik, Subramanian G Mani, Rosen Antony, Ladenson Paul W
Abstract excerpt
CONTEXT: Thyroid dysfunction is a common complication of interferon-α (IFNα) therapy, with many phenotypic patterns and the potential for significant morbidity. OBJECTIVE: Our objective was to gain mechanistic insight and predict clinical presentations by determining the risk factors for distinct subtypes of IFNα-induced thyroid dysfunction. DESIGN: ACHIEVE-1, a randomized trial conducted from 2005-2009, compared...
Topics
- Adult
- Antiviral Agents
- Cohort Studies
- Delayed-Action Preparations
- Female
- Hepatitis C
- Humans
- Hypothyroidism
- Interferon-alpha
- Logistic Models