Article
Genome-wide copy number variation association study in anorexia nervosa.
Molecular psychiatry - 1 May 2025
Walker Alicia, Karlsson Robert, Szatkiewicz Jin P, Thornton Laura M, Yilmaz Zeynep, Leppä Virpi M, Savva Androula, Lin Tian, Sidorenko Julia, McRae Allan, Kirov George, Davies Helena L, Fundín Bengt T, Chawner Samuel J R A, Song Jie, Borg Stina, Wen Jia, Watson Hunna J, Munn-Chernoff Melissa A, Baker Jessica H, Gordon Scott, Berrettini Wade H, Brandt Harry, Crawford Steven, Halmi Katherine A, Kaplan Allan S, Kaye Walter H, Mitchell James, Strober Michael, Woodside D Blake, Pedersen Nancy L, Parker Richard, Jordan Jennifer, Kennedy Martin A, Birgegård Andreas, Landén Mikael, Martin Nicholas G, Sullivan Patrick F, Bulik Cynthia M, Wray Naomi R
Abstract excerpt
This study represents the first large-scale investigation of rare (<1% population frequency) copy number variants (CNVs) in anorexia nervosa (AN). Large, rare CNVs are reported to be causally associated with anthropometric traits, neurodevelopmental disorders, and schizophrenia, yet their role in the genetic basis of AN is unclear. Using genome-wide association study (GWAS) array data from the Anorexia Nervosa...
Read the complete abstract on PubMedTopics
- Humans
- Anorexia Nervosa