Article
Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa.
Molecular psychiatry - 1 May 2018
Huckins L M, Hatzikotoulas K, Southam L, Thornton L M, Steinberg J, Aguilera-McKay F, Treasure J, Schmidt U, Gunasinghe C, Romero A, Curtis C, Rhodes D, Moens J, Kalsi G, Dempster D, Leung R, Keohane A, Burghardt R, Ehrlich S, Hebebrand J, Hinney A, Ludolph A, Walton E, Deloukas P, Hofman A, Palotie A, Palta P, van Rooij F J A, Stirrups K, Adan R, Boni C, Cone R, Dedoussis G, van Furth E, Gonidakis F, Gorwood P, Hudson J, Kaprio J, Kas M, Keski-Rahkonen A, Kiezebrink K, Knudsen G-P, Slof-Op 't Landt M C T, Maj M, Monteleone A M, Monteleone P, Raevuori A H, Reichborn-Kjennerud T, Tozzi F, Tsitsika A, van Elburg A, Collier D A, Sullivan P F, Breen G, Bulik C M, Zeggini E
Abstract excerpt
Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls....
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