Article
Variability, heritability and environmental determinants of human plasma N-glycome.
Journal of proteome research - 1 Feb 2009
Knezević Ana, Polasek Ozren, Gornik Olga, Rudan Igor, Campbell Harry, Hayward Caroline, Wright Alan, Kolcic Ivana, O'Donoghue Niaobh, Bones Jonathan, Rudd Pauline M, Lauc Gordan
Abstract excerpt
Plasma glycans were analyzed in 1008 individuals to evaluate variability and heritability, as well as the main environmental determinants that affect glycan structures. By combining HPLC analysis of fluorescently labeled glycans with sialidase digestion, glycans were separated into 33 chromatographic peaks and quantified. A high level of variability was observed with the median ratio of minimal to maximal values...
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