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TIPE Inhibits Ferroptosis in Colorectal Cancer Cells by Regulating MGST1/ALOX5

8 Nov 2024

Abstract excerpt

TIPE is a protein highly expressed in various cancers that promotes ferroptosis in colorectal cancer cells. Ferroptosis is a nonapoptotic cell death caused by lipid peroxidation, and microsomal glutathione transferase 1 (MGST1) is a critical enzyme that resists lipid peroxidation. This study explored how TIPE regulates MGST1 expression to inhibit ferroptosis and promote colorectal cancer proliferation. TIPE was...

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PMID: 39513751
DOI: 10.1158/1541-7786.mcr-24-0433

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