Article
An Autoimmunogenic and Proinflammatory Profile Defined by the Gut Microbiota of Patients With Untreated Systemic Lupus Erythematosus.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Feb 2021
Chen Bei-di, Jia Xin-Miao, Xu Jia-Yue, Zhao Li-Dan, Ji Jun-Yi, Wu Bing-Xuan, Ma Yue, Li Hao, Zuo Xiao-Xia, Pan Wen-You, Wang Xiao-Han, Ye Shuang, Tsokos George C, Wang Jun, Zhang Xuan
Abstract excerpt
OBJECTIVE: Changes in gut microbiota have been linked to systemic lupus erythematosus (SLE), but knowledge is limited. Our study aimed to provide an in-depth understanding of the contribution of gut microbiota to the immunopathogenesis of SLE. METHODS: Fecal metagenomes from 117 patients with untreated SLE and 52 SLE patients posttreatment were aligned with 115 matched healthy controls and analyzed by...
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