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Actionable Structural Variant Detection via RNA-NGS and DNA-NGS in Patients With Advanced Non–Small Cell Lung Cancer

4 Nov 2024

Abstract excerpt

Importance: The National Comprehensive Cancer Network (NCCN) guidelines for non-small cell lung cancer suggest that RNA next-generation sequencing (NGS) may improve the detection of fusions and splicing variants compared with DNA-NGS alone. However, there is limited adoption of RNA-NGS in routine oncology clinical care today. Objective: To analyze clinical evidence from a diverse cohort of patients with advanced...

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PMID: 39495511
DOI: 10.1001/jamanetworkopen.2024.42970

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