Article
Differential susceptibility to hypoxia in hypoxia-inducible factor 1-alpha (HIF-1α)-targeted freshwater water flea Daphnia magna mutants.
Marine pollution bulletin - 1 Dec 2024
Lee Yoseop, Byeon Eunjin, Lee Jin-Sol, Maszczyk Piotr, Kim Hyung Sik, Sayed Alaa El-Din H, Yang Zhou, Lee Jae-Seong, Kim Duck-Hyun
Abstract excerpt
The water flea, Daphnia magna, serves as a key model organism for investigating the response of aquatic organisms to environmental stressors, including hypoxia. Hypoxia-inducible factor 1-alpha (HIF-1α) is a central regulatory protein involved in the cellular response to hypoxic conditions. In this study, we used CRISPR/Cas9 gene editing to create D. magna mutant lines with targeted alterations in the HIF-1α...
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