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Article

Hyperuricemia suppresses lumican, exacerbating adverse remodeling after myocardial infarction by promoting fibroblast phenotype transition.

Journal of translational medicine - 31 Oct 2024

Zhuang Zehao, Liu Ao, Zhang Jinghong, Han Shuangjian, Tang Lu, Yu Tingting, Shi Yiping, Li Hui, Yang Heng, Bai Peiyuan, Tang Yanhua

Abstract excerpt

BACKGROUND: Hyperuricemia is independently associated with a poor prognosis in patients with myocardial infarction (MI). Furthermore, MI induces activation of the repair response in local fibroblasts, resulting in extracellular matrix accumulation that generates a stable fibrotic scar in the infarcted area. However, researchers have not determined whether hyperuricemia affects fibroblast activation and its...

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Identifiers

PMID: 39482719
DOI: 10.1186/s12967-024-05778-4
PMCID: PMC11526644

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