Effects of oxycodone on placental lineages: Evidence from the transcriptome profile of mouse trophoblast giant cells

Abstract excerpt

Pregnant women are often prescribed or abuse opioid drugs. The placenta is likely the key to understanding how opioids cause adverse pregnancy outcomes. Maternal oxycodone (OXY) exposure of pregnant mice leads to disturbances in the layer of invasive parietal trophoblast giant cells (pTGC) that forms the interface between the placenta and uterus. These cells are analogous to extravillous trophoblasts of the human...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Birth, Development, and Health
• Share to Pregnancy and preeclampsia studies
• Share to Prenatal Substance Exposure Effects