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Article

Immune cells mediate the causal relationship between uveitis and colorectal cancer via Mendelian randomization analysis.

Scientific reports - 29 Oct 2024

Zhou Li, Zhang Jiwang

Abstract excerpt

Colorectal cancer (CRC) is one of the most common and deadly malignancies worldwide, and immune regulation plays a critical role in its development. This study investigates the causal relationships between uveitis, specific immune cell traits, and CRC using Mendelian Randomization (MR) analyses. A total of 21 single nucleotide polymorphisms (SNPs) associated with uveitis were identified, and the analysis revealed...

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Colorectal Neoplasms
Genetic Predisposition to Disease
HLA-DR Antigens
Mendelian Randomization Analysis
Monocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Identifiers

PMID: 39472473
DOI: 10.1038/s41598-024-77758-z
PMCID: PMC11522305

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