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Article

Pharmacogenetics of tuberculosis treatment toxicity and effectiveness in a large Brazilian cohort.

Pharmacogenetics and genomics - 1 Feb 2025

Amorim Gustavo, Jaworski James, Yang Jing, Cordeiro-Santos Marcelo, Kritski Afrânio L, Figueiredo Marina C, Turner Megan, Andrade Bruno B, Velez Edwards Digna R, Santos Adalberto R, Rolla Valeria C, Sterling Timothy R, Haas David W

Abstract excerpt

BACKGROUND: Genetic polymorphisms have been associated with risk of antituberculosis treatment toxicity. We characterized associations with adverse events and treatment failure/recurrence among adults treated for tuberculosis in Brazil. METHODS: Participants were followed in Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil. We included persons with culture-confirmed drug-susceptible...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39470346
DOI: 10.1097/FPC.0000000000000552
PMCID: PMC11695165

Genes

NAT2
GSTM1
METTL17
PRSS57
SLCO1B1
VTI1A

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